Local FK506 delivery at the direct nerve repair site improves nerve regeneration
نویسندگان
چکیده
منابع مشابه
Local delivery of glial cell line-derived neurotrophic factor improves facial nerve regeneration after late repair.
OBJECTIVES/HYPOTHESIS Facial nerve regeneration is limited in some clinical situations: in long grafts, by aged patients, and when the delay between nerve lesion and repair is prolonged. This deficient regeneration is due to the limited number of regenerating nerve fibers, their immaturity and the unresponsiveness of Schwann cells after a long period of denervation. This study proposes to apply...
متن کاملRepair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: effect on nerve regeneration.
We investigated the use of direct lengthening of the distal stump of a peripheral nerve to compare the results of nerve regeneration using the direct lengthening method with simple end-to-end suture and autografting in rats. A segment 10 mm long was resected from the rat sciatic nerve (n=18 in each group). The distal nerve stump was fixed to a ring and pulled at a rate of 1 mm/day for 20 days u...
متن کاملAbstract 134: FK506 Delivering Conduit For Peripheral Nerve Regeneration
PURPOSE: Following a peripheral nerve injury, nerve gaps require grafts or conduits to connect the two nerve ends. There is a clinical need to improve functional recovery following nerve injury and local release of neurotrophic factors is one way to improve outcomes. FK506, an FDA approved small molecule, has been shown to enhance axon growth in vitro and peripheral nerve regeneration in vivo. ...
متن کاملNanotechnology for peripheral nerve regeneration
Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...
متن کاملNanotechnology for peripheral nerve regeneration
Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...
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ژورنال
عنوان ژورنال: Muscle & Nerve
سال: 2019
ISSN: 0148-639X,1097-4598
DOI: 10.1002/mus.26656